Performance Edge® introduces the latest in researched and scientifically-advanced ingredients. D-Aspartic Acid, an innovative breakthrough in cutting-edge performance nutrition, is now available as a high-quality, 100% pharmaceutical-grade daily supplement.
DAA stimulation increases cyclic AMP (cAMP) in the "receiving" nerves. In the neuroendocrine axis (the hypothalamus and pituitary), DAA enhances the release of GnRH (the hormone that tells the pituitary that testosterone concentration is falling), as well as the production of two other hormones, oxytocin and vasopressin.1,2
In a study published in the journal Reproductive Biology and Endocrinology,3 performed by scientists and physicians in Italy, the role and mechanisms of DAA relating to testosterone and LH in humans and rats was evaluated and reported. To summarize the study's finding: DAA was found to accumulate in the pituitary and testes (in rats); in humans, DAA increased circulating (blood) LH by 33 percent (p<0.0001) and testosterone concentration by 42 percent (p<0.0082) on average, in men aged 27-37 years, after taking slightly more than 3 grams a day, orally.
1. D'Aniello A, Di Fiore MM, et al. Occurrence of D-aspartic acid and N-methyl-D-aspartic acid in rat neuroendocrine tissues and their role in the modulation of luteinizing hormone and growth hormone release. FASEB J, 2000 Apr;14(5):699-714.
2. D'Aniello A. D-Aspartic acid: an endogenous amino acid with an important neuroendocrine role. Brain Res Rev, 2007 Feb;53(2):215-34.
3. Topo E, Soricelli A, et al. The role and molecular mechanism of D-aspartic acid in the release and synthesis of LH and testosterone in humans and rats. Reprod Biol Endocrinol, 2009 Oct 27;7:120.